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BRAINBox Solutions announces the new U.S. patent allowance

by techsterhub bureau
October 5, 2022
Reading Time: 2 mins read
BRAINBox Solutions announces the new U.S. patent allowance

BRAINBox Solutions, Inc announced today that the U.S. Patent & Trademark Office (PTO) issued a notice of allowance for a patent covering methods for detection of mild traumatic brain injury (mTBI), also known as concussion, using Brain Derived Neurotrophic Factor (BDNF). BDNF is an important component of the biomarker panel in the multi-modal diagnostic prognostic and prognostic solutions the company is developing for mTBI.

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“BRAINBox’s test is the first to integrate blood biomarkers with functional testing for both the diagnosis and prognosis of mild TBI,” said Donna Edmonds, BRAINBox Solutions’ Chief Executive Officer. “The new BDNF patent is an important addition to our broad, worldwide portfolio of patents covering biomarkers related to various aspects of diagnostic use. Incorporating BDNF into our TBI biomarker panels enhances the competitive advantage of our algorithms to generate an objective TBI score to help guide healthcare decision making.” She noted that BRAINBox Solutions’ current intellectual property portfolio includes 17 issued patents protecting a portfolio of more than 30 proprietary TBI biomarkers and 18 pending applications directed to other novel TBI biomarkers.

The newly allowed patent is based on BRAINBox Solutions’ discovery that a decrease in blood levels of BDNF alone is sensitive and specific in the detection of mild TBI. The claims in the new patent also protect the BDNF discovery alone, and in combination with other biomarkers, including GFAP, S100B, NSE, MT3, and NRGN. The new patent covers both diagnosis of TBI and patient monitoring post-injury, particularly for determining return to work or play. The company’s pending patents also cover patient risk stratification based upon TBI symptoms and the correlation with specific neuroimaging features in CT and advanced MRI. In this context, the results of the TBI biomarker test may be used to justify a more definitive neuroimaging test such as MRI. The work underlying the discoveries in the company’s patent portfolio established important relationships to guide clinical care decisions at multiple steps in the care pathways of TBI, and aid eligibility decisions in clinical trials for treatments for TBI.

 

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